When used in combination with ipilimumab, opdivo is usually given every 3 weeks, for a total of 4 doses. Dm1, the cytotoxic component of kadcyla, may cause serious adverse reactions in breastfed infants based on its mechanism of action. Do not mix kadcyla, or administer as an infusion, with other medicinal products. Now that you have completed introduction to microsoft publisher 2007, the next recommended class is intermediate microsoft publisher 2007. Trastuzumab emtansine also known as adotrastuzumab emtansine and sold under the trade name kadcyla, is an antibodydrug conjugate consisting of the humanized monoclonal antibody trastuzumab herceptin covalently linked to the cytotoxic agent dm1. Mitoxantrone hydrochloride mitoxantrone hydrochloride this product information is intended only for residents of the united states. Opdivo is usually given every 2 weeks or 4 weeks depending on the dose you are receiving. The icon is blank when you insert an object or a file into. Appropriate procedures for the preparation of chemotherapeutic drugs should be used.
Metastatic breast cancer mbc kadcyla, as a single agent, is indicated for the treatment of patients with her2positive, metastatic breast cancer who previously received trastuzumab and a. To do this, you use one of the methods in the following examples. The antibody is the humanized antiher2 igg1, trastuzumab. Initial approval criteria 1 coverage is provided in the following conditions. Kadcyla 100 mg vial 1 vial every 21 days kadcyla 160 mg vial 3 vials every 21 days b. Dailymed kadcyla adotrastuzumab emtansine injection. Sps can dispense genentech medicines to your office. Kadcyla adotrastuzumab emtansine is a new class of chemotherapy drug called an antibodydrug conjugate used to treat breast cancer. Kadcyla is a prescription medicine used as an adjuvant after surgery treatment for her2positive early breast cancer when the patient has taken neoadjuvant before surgery treatment including a taxane and trastuzumab herceptin and there is cancer remaining in the tissue removed during surgery. How to insert and extract pages from a pdf file youtube. Here are the other common side effects of kadcyla or adotrastuzumab emtansine muscle pain, joint pain, tired feeling, headache, bleeding, and easy bruising. You insert an object or a file into a document, presentation, spreadsheet, or other microsoft office 2003 or microsoft office xp file. In intermediate microsoft publisher, you will learn how to create your own custom animations, and insert tables, videos, and hyperlinks into your presentations. To add an interactive link to your pdf document, follow these steps.
When viewing a pdf file in adobe acrobat creative suite 5, you can add links for email addresses, web addresses, and references to other pages. A healthcare provider will give you this injection. Insert a pdf file as an object into a powerpoint presentation to insert a pdf file as an object into a powerpoint presentation, you make it available to those youre sharing the presentation with. Kadcyla her2 positive breast cancer forecast and market analysis to 2023. Kadcyla, as a single agent, is indicated for the treatment of patients with her2positive, metastatic breast cancer who previously received trastuzumab and a taxane, separately or in combination. Kadcyla is given through an infusion into a vein intravenous, iv the amount of kadcyla that you will receive depends on many factors, including your weight, your general health or other health problems, and the type of cancer or condition being treated. Abraxane is indicated for the firstline treatment of locally advanced or metastatic nonsmall cell lung cancer, in combination with carboplatin, in patients who are not candidates for curative surgery or radiation therapy. Trastuzumab alone stops growth of cancer cells by binding to the her2 receptor, whereas trastuzumab emtansine undergoes receptormediated. Word will convert the pdf to editable text and you can then copy and paste that text into your office document. There is no information regarding the presence of adotrastuzumab emtansine in human milk, the effects on the breastfed infant, or the effects on milk production. Options after kadcyla for her2positive breast cancer.
It uses a similar set of steps to inserting as an image, but does something different as a result. Trastuzumab emtansine tdm1 is one adc that targets her2 and has been shown to cause significant improvements in progressionfree survival pfs in patients with prior progression on antiher2 agents. Kadcyla adotrastuzumab emtansine magellan provider. Kadcyla access solutions works with sps to help patients receive their medicines. Your healthcare provider will give you opdivo into your vein through an intravenous iv line over 30 minutes. Do not administer halaven on day 1 or day 8 for any of the following. Links are attached to a region of a page, which you identify with the link tool. Closely monitor the infusion site for possible subcutaneous infiltration during drug administration see warnings and precautions 5. Microsoft publisher is a wonderful tool for creating flyers, brochures, newsletters, cards, banners, certificates and much more. By delivering the emtansine chemotherapy directly into the breast cancer cells, the chemotherapy part of kadcyla acts in a targeted way.
The sps can also provide coverage and reimbursement support. Kadcyla usually is given every 3 weeks in a doctors office. You can create a document from scratch if you wish, but its much easier to use the catalog of templates that comes with the software. Kadcyla is given intravenously, which means the medicine is delivered directly into your bloodstream through an iv or port. In order to improve traceability of biological medicinal products, the tradename and the batch number of the administered product should be clearly recorded or stated in the patient file. Criteria for approval breast cancer authorization of 3 months may be granted for members who are prescribed kadcyla as a single agent for her2positive recurrent or metastatic breast cancer when one of the following criteria is met. Kadcyla kadcyla adotrastuzumab emtansine, injection for intravenous use, as a single agent, is indicated for the treatment of patients with her2positive, metastatic breast cancer who previously received trastuzumab and a taxane, separately or in combination. People diagnosed with metastatic disease get kadcyla every 3 weeks unless the cancer grows or unacceptable side effects develop. Kadcyla package insert, 220 revision nccn guidelines on breast cancer v 2.
Assess for peripheral neuropathy and obtain complete blood cell counts prior to each dose. Full prescribing information 1 indications and usage zaltrap, in combination with. I tried following code but it keeps opening word but attaches pdf file but does not embed pdf as a object in the body of email. First diagnosed at stage ii in 2006 with recurrence in september 20. The small molecule cytotoxin, dm1, is a microtubule inhibitor. Genentechroche is a human epidermal growth factor receptor 2 her2 antibodydrug conjugate that comprises the humanized antiher2 igg1 antibody trastuzumab linked to the antimitotic agent mertansine a maytansine derivative. Using a sterile syringe, slowly inject 5 ml of sterile water for injection into the 100 mg kadcyla vial, or 8 ml of sterile water for injection into the 160 mg kadcyla vial to yield a solution containing 20 mgml. She started on kadcyla this past december after herceptinperjeta combo stopped working. Inspect the reconstituted solution for particulates and discoloration.
Upon binding to subdomain iv of the her2 receptor, adotrastuzumab emtansine undergoes receptormediated internalization and. These partners have agreed to distribute only products purchased directly from genentech and not to distribute kadcyla through secondary channels. Tell your caregivers if you feel any burning, pain, or swelling around the iv needle when kadcyla is injected. Page 1 of 14 highlights of prescribing information these highlights do not include all the information needed to use libtayo safely and effectively. Kadcyla adotrastuzumab emtansine is indicated, as a single agent, for the treatment of patients with her2positive, metastatic breast cancer who previously received trastuzumab and a taxane, sepmately or in combination. Adotrastuzumab emtansine is a her2targeted antibodydrug conjugate. Patients should have either received prior therapy for metastatic disease, or. Im new here to this forum and am part of my moms support team. Find out how to insert and extract one or more pages while working with a pdf file. If youre looking to insert the contents of your pdf file into an office file, as opposed to simply inserting the pdf as an attachment, then your best bet is to open that pdf with word 20 or 2016.
Kadcyla can only be obtained with a prescription and treatment should be prescribed by a doctor and given under the supervision of a healthcare professional who is experienced in the treatment of cancer patients. Role of trastuzumab emtansine in the treatment of her2. Select patients for therapy based on an fdaapproved companion diagnostic for kadcyla. Cl 110 medication order kadcyla v2cl 110 medication order kadcyla page2 of 2 sept. This medicine must be given slowly, and the infusion can take 30 to 90 minutes to complete. Download, view or print all the forms and documents you need to get started with kadcyla access solutions, including enrollment forms, tips and checklists. She is age 70 with advanced her2positive breast cancer liver and bone mets. Kadcyla adotrastuzumab emtansine all other uses of adotrastuzumab emtansine are considered investigational, including but not limited to combination treatment with different agents, and treatment of gastric cancer.
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